regulatory protein tat in CNS tissues
نویسندگان
چکیده
Department of Neuropathology, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Bethune University of Medical Sciences, Changchun, Peoples Republic of China; Department of Neurology, University of Kentucky, Lexington, KY 40536-0284; USA; Department of Pathology and Laboratory Medicine, University of Kansas, Medical Center, Kansas City, KS, USA and Laboratory of Viral Pathogenesis, Marion Merrell Dow Foundation, University of Kansas, Medical Center, Kansas City, KS, USA
منابع مشابه
Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with progressive multifocal leukoencephalopathy.
HIV-1 infection can lead to severe central nervous system (CNS) clinical syndromes in more than 50% of HIV-1 positive individuals. Progressive multifocal leukoencephalopathy (PML) is the frequent opportunistic infection of the CNS which is seen in as high as 5% of AIDS patients. Results from previous cell culture studies showed that the HIV-1 regulatory protein, Tat can potentiate transcription...
متن کاملMolecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat.
The broad range of histological lesions associated with HIV-1 are somewhat subtle relative to the clinical manifestations that occur as a result of HIV infection. Although it is clear that HIV has a causative role in CNS disease, dementia appears to be a consequence of the infiltration of inflammatory cells and cytokine dysregulation rather than the amount of virus in CNS. The HIV transregulato...
متن کاملDesigning and analyzing the structure of Tat-BoNT/A(1-448) fusion protein: An in silico approach
Clostridium botulinum type A (BoNT/A) produces a neurotoxin recently found to be useful as an injectable drug for the treatment of abnormal muscle contractions. The catalytic domain of this toxin which is responsible for the main toxin activity is a zinc metalloprotease that inhibits the release of neurotransmitter mediators in neuromuscular junctions. A cell penetrating cationic peptide, Tat, ...
متن کاملExamination of MHC-1 Expression by J774 Macrophage Cells Treated with Recombinant Protein HIV-1 Tat 49-59 / HPV16, 18, 6, 11 E7 In Vitro
Background and purpose: Human papillomavirus (HPV) is one of the infectious agents that causes genital and non-genital warts and skin cancers in humans. The E7 protein of this virus is one of the small oncoproteins that may be the main target in therapeutic vaccines. E7 protein with HIV-1 Tat peptide (49-59), plays a protective role that cause immune Th1 and CTLs response. The aim of this study...
متن کاملHIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB.
The human immunodeficiency virus type-1 (HIV-1) infects microglia, macrophages, and astrocytes in the central nervous system (CNS) and may cause severe neurological diseases, such as AIDS-related dementias or progressive encephalopathies, as a result of CNS inflammation and neurotrophin signaling defects associated with expression of viral antigens and HIV-1 replication in the brain. The HIV Ta...
متن کامل